Gender differences arise in managing obesity because of the dissimilarity in fat distribution and response to hormones between males and females, with overall different responses to interventions intended for weight loss. Compared to men, women have an increased tendency to accumulate fat of subcutaneous origin. This is mainly distributed within the hips and the regions of the thighs, although the male gender predisposedly accumulates visceral fat. The IOMC focuses on these gender-specific challenges, offering a platform for exploring tailored strategies and treatments to address obesity in both men and women and enhancing personalized care for diverse populations. Weight management in women can be further complicated by hormonal fluctuations associated with menstruation, pregnancy, and menopause. Social and psychological factors may also influence gender differences in obesity treatment outcomes.