Description: The development and progress of obesity highly depend on one critical factor: hormonal imbalance. IOMC covers complex issues involving hormonal imbalance and obesity by bringing together professionals and discussing new approaches to restore the disturbed hormonal balance and improve metabolic health. The disruption in any of these hormones—leptin, insulin, ghrelin, or cortisol—all involved in appetite and fat storage regulation can inhibit fat combustion and energy expenditure. For example, leptin resistance increases appetite and lowers energy use, and insulin resistance promotes fat accretion and sustains metabolic dysregulation. The mechanisms by which these hormonal pathways work can be conceptualized as a potential point for intervention to treat obesity.