One of the most significant risk factors for type 2 diabetes is insulin signaling disrupted by excessive fat, particularly visceral adiposity, resulting in insulin resistance. Chronic inflammation, disturbed secretion of adipokines, and blunted glucose metabolism contribute significantly to the development of T2D. Management of obesity with weight loss, physical activity, and pharmacotherapy considerably reduces the risk of type 2 diabetes or delaying its onset. The International Obesity and Metabolism Conference-IOMC focuses on the integrative link between obesity and T2D, underscoring studies on prevention, early detection, and new therapeutic approaches regarding these two interconnected metabolic disorders.