Description: Whereas pharmacotherapies for treating obesity are still greatly needed, lately, medications directed against appetite and fat absorption, along with metabolic pathways, have established an essential role in managing weight. Thus, IOMC presented the perfect opportunity to discuss the new developments related to the pharmacotherapy of obesity, thus initiating collaboration among researchers, clinicians, and industry leaders about new opportunities for effective obesity treatment options. However, challenges persist and are related to variable patient response and side effects, which are daunting issues. Concerns about its long-term sustainability also remain a challenge. New classes of drugs, like GLP-1 agonists and dual-receptor agents, exemplify that further improvements in efficacy and safety are achievable. Interest has hence shifted toward pharmacological treatment optimization for obesity and the deployment of targeted intervention at the very core of the mechanisms that drive this disease process.