2nd Edition of International Obesity and Metabolism Conference 2026

Speakers - IOMC2025

Ajit Kayal

  • Designation: Sri Balaji Vidyapeeth University
  • Country: India
  • Title: Obesity and Chronic Pain

Abstract

Introduction

Obesity, a condition characterized by excessive body fat, has become a global epidemic affecting millions of individuals. It is closely linked with numerous health complications, among which chronic pain stands out as a significant and debilitating issue. Chronic pain, defined as persistent pain lasting longer than three to six months, can severely impact one's quality of life and daily functioning.

The Connection Between Obesity and Chronic Pain

Several studies have established a strong correlation between obesity and chronic pain. The excess weight carried by individuals with obesity places additional stress on the musculoskeletal system, leading to conditions such as osteoarthritis, lower back pain, and joint pain. According to a study published in the journal *Pain Medicine*, individuals with obesity are at a higher risk of developing chronic pain conditions compared to those with a healthy weight (Okifuji, Donaldson, Barck, & Fine, 2010).

Inflammation and Pain

One of the primary mechanisms linking obesity and chronic pain is inflammation. Adipose tissue, especially visceral fat, secretes pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). These cytokines contribute to a state of chronic low-grade inflammation, which can sensitize pain receptors and exacerbate pain sensations (Samad, Ruf, & Woolf, 2001). Research published in the journal *Obesity* indicates that higher levels of these inflammatory markers are associated with increased pain sensitivity and frequency in obese individuals (Tashani et al., 2017).

Mechanical Stress

The mechanical stress exerted by excess body weight is another critical factor contributing to chronic pain. Joints, particularly weight-bearing ones like the knees and hips, are subjected to heightened pressure, accelerating the wear and tear of cartilage and leading to conditions such as osteoarthritis. A study in the journal *Arthritis & Rheumatology* found that obesity significantly increases the risk of developing knee osteoarthritis, which can result in severe pain and disability (Bliddal & Christensen, 2009).

Psychological Factors

The relationship between obesity and chronic pain is not solely physiological; psychological factors also play a substantial role. Depression, anxiety, and emotional distress are more prevalent among individuals with obesity, and these conditions can amplify the perception of pain. The *Journal of Pain Research* highlights that obese individuals with comorbid depression report higher levels of pain and greater functional impairment than those without depression (Riddle, Wade, & Price, 2011).

Management Strategies

Addressing chronic pain in individuals with obesity requires a multifaceted approach that targets both the physical and psychological aspects of the condition.

Weight Loss

Weight loss is a fundamental strategy in alleviating obesity-related chronic pain. Even modest reductions in body weight can lead to significant improvements in pain levels and overall function. A study in the journal *Pain* demonstrated that a 10% reduction in body weight resulted in a 20% decrease in pain intensity among obese individuals with knee osteoarthritis (Messier et al., 2013).

Exercise

Regular physical activity is crucial in managing both obesity and chronic pain. Exercise helps reduce body weight, improve joint mobility, and release endorphins, which are natural pain relievers. Low-impact activities such as swimming, walking, and cycling are particularly beneficial. According to the *American Journal of Preventive Medicine*, engaging in regular exercise is associated with lower pain levels and better physical function in obese individuals (Kolt et al., 2010).

Psychological Interventions

Cognitive-behavioral therapy (CBT) and other psychological interventions can help address the emotional and cognitive aspects of chronic pain. CBT focuses on changing negative thought patterns and behaviors that contribute to pain perception and coping. A review in the *Journal of Clinical Psychology* found that CBT effectively reduces pain severity and improves psychological well-being in obese individuals with chronic pain (Hoffman et al., 2007).

Conclusion

The interplay between obesity and chronic pain is complex and multifactorial, involving physiological, mechanical, and psychological factors. Effective management requires a comprehensive approach that includes weight loss, exercise, and psychological support. By addressing these aspects, individuals with obesity and chronic pain can achieve significant improvements in their quality of life and overall health.