2nd Edition of International Obesity and Metabolism Conference 2026

Abstract

Background: Obesity is a global health challenge, yet sustained weight loss with favorable body composition remains difficult. This case demonstrates the efficacy of intensive lifestyle modification (ILM) combined with meal replacement (MR) in achieving significant, sustainable weight loss over 4 years.

Case Presentation: A 52-year-old Thai female with severe obesity (BMI 44.1 kg/m², weight 102 kg) enrolled in an ILM+MR program including soy-based meal replacement twice daily for 8 weeks, nutritional counseling, structured physical activity, and behavioral modification through group therapy.

Results: At 8 weeks: weight 86 kg (15.7% reduction), fat mass decreased 8.2%, muscle mass increased 2.1%, visceral fat reduced from 30 to 24. At 1 year: weight 70 kg (31.4% reduction), progression from Class III to Class I obesity. At 2 years: weight 59 kg (42.2% reduction), BMI

25.5 kg/m². At 4 years: weight 53 kg (48.0% sustained reduction), BMI 22.9 kg/m² (normal weight), body fat 29.5%, muscle mass 26.8%, and visceral fat level 6.

Conclusion: ILM with meal replacement achieved 48.0% weight loss maintained over 4 years with exceptional body composition improvements. This case demonstrates long-term efficacy in severe obesity, achieving normal BMI with sustained metabolic health improvements.